CYBB and Parkinson disease: Demonstration of synthesis of Nox2, p47phox and p67phox, NADPH oxidase subunits that are necessary for mitochondrial complex I-Nox responses to cellular stress in dopaminergic neurons in intact adult substantia nigra, together with evidence of a stress-elicited complex I-Nox response in a MPP+ treated dopaminergic cell line (N27) lends credence to the idea that these events are important in PD neuropathogenesis.