Malignant pleural mesothelioma has one of the highest VEGF levels among solid tumours (Linder et al, 1998), VEGFR-2 expression is detected in most MPM samples (Nutt et al, 2009), and an increased vascularisation is a poor prognostic factor (Edwards et al, 2003). The gene discussed is VEGFA; the disease is malignant pleural mesothelioma.