Whereas nigral injection of HSV-IRS2 did not increase striatal DAT cell surface expression in LF animals (compared to GFP injected controls), viral IRS2 overexpression in HF animals clearly rescued DAT plasma membrane expression to the level detected in LF controls (Fig. 7A; HF IRS2 vs. HF GFP, *p<0.05 by one-way ANOVA, followed by Bonferroni post hoc test). The gene discussed is SLC6A3; the disease is hydrops fetalis.