Work by Simar et al. in the adult rat revealed an interaction between maternal obesity and postnatal overnutrition on skeletal muscle metabolism, a postweaning HF diet exerted an additive effect to that of maternal obesity on body weight and skeletal muscle markers of glucose and lipid metabolism but not on plasma glucose and insulin levels, suggesting that maternal obesity and postnatal overnutrition impair skeletal muscle function via different mechanisms [58]. The gene discussed is INS; the disease is overnutrition.