TG2 has been implicated in the drug resistance and survival of cancer cells by modulating caspase-3 and NF-κB activity [17-20] and in the in vitro migration and invasion of tumor cells through increased cell attachment via β-integrins and fibronectins with extracellular TG2 [21-23] and increases in matrix metalloprotease-2 (MMP-2) expression [24]. This evidence concerns the gene TGM2 and cancer.