Breast cancer cells with high TG2 levels (cont_MB231) showed rapid growth of primary tumor masses in the mammary fatpads compared with TG2-knocked-down cells (shTG2_MB231#1, Figure 4a and 4c) and IL-6-knocked-down cells (shIL-6_MB231#6, Figure 4b and 4c). Here, IL6 is linked to neoplasm.