IL6 and cancer: To evaluate whether modulation of TG2 expression levels in the given cancer cells leads to a change in IL-6 production, we compared IL-6 levels in control empty vector-transfected TG2 high-expressing cells, MDA-MB-231 (cont_MB231), and their TG2-knocked-down cells by using shRNA vectors (shTG2_MB231; Figure 2a).