Whether a blind marrow biopsy may still be warranted in patients with indolent lymphoma for whom chemotherapy may not be offered if there is no evidence of bone marrow involvement by lymphoma, or in patients with marrow population changes related to factors other than chemotherapy only, for example, G-CSF treatment, bone marrow dysplasia, prior chemo- or radiation treatment, and so forth, needs further clinical investigation. The gene discussed is CSF3; the disease is lymphoma.