Irrespective of the nature of underlying mechanism, the misfolded conformation dependent loss of N-CoR can contribute to the malignant growth and transformation of NSCLC cells through multiple mechanisms; such as loss of normal tumor suppressive function of N-CoR due to misfolding, neutralization of ER stress due to the degradation of misfolded N-CoR and possible gain of aberrant function by the misfolded N-CoR protein. This evidence concerns the gene NCOR1 and neoplasm.