PTGER3 and toxic epidermal necrolysis: In our earlier genome-wide association study in Japanese SJS/TEN patients with severe ocular surface complications we found associations with 6 single nucleotide polymorphisms (SNPs) in the prostaglandin E receptor 3 (EP3) gene (PTGER3) and we documented that compared with the controls, EP3 expression was markedly reduced in the conjunctival epithelium of SJS/TEN patients with severe ocular complications [3].