Because the cytoplasmic domain of MUC1 C-ter (MUC1-CD) has been linked to transcriptional regulation of VEGF [15]–[17] and our data show that the levels of MUC1 C-ter in the PMF – which encompasses cytoplasmic components - are related to the intrinsic Δψm (Figure 1B), we investigated the effect of siRNA induced MUC1 down regulation on steady state VEGF secretion in colonic carcinoma cells with different Δψm. Here, VEGFA is linked to colon carcinoma.