If developmental neuronal migration is deficient in the brains of people with schizophrenia, this could lead to an accumulation of IWMNs under the cortex, and higher numbers of IWMNs in individuals with schizophrenia that may constrain the immature neurons reaching the cortex and drive the negative correlation between IWMN density and DCX mRNA expression in the disease state. The gene discussed is DCX; the disease is schizophrenia.