TF and Tangier disease: As expected, untreated Hjv−/− mice exhibited very high serum iron indices as compared to wt counterparts (transferrin saturation: 93.8±4.3 vs 50.8±7.5%, p<0.0001; serum iron: 57.2±8.6 vs 36.5±3.6 μmol/L, p<0.0001; serum ferritin: 10,785.7±6,120.5 vs 595±77 μg/dL, p<0.0001), consistently with an iron overload phenotype.