PIK3CA and colorectal carcinoma: In support of this, we found comparable sensitivity to in vitro NVP-BEZ235 treatment in PIK3CA mutant (HCT116, kinase domain mutation; DLD-1, helical domain mutation) and PIK3CA wild-type (SW480) CRC cell lines, as well as in matched PIK3CA mutant and wild-type isogenic cell lines.