CD4 and colitis: In accordance with our previous demonstration of regression of Peyer's patches in Gαi2−/− mice prior to colitis [2], CLP and ILF were not observed in inflamed Gαi2−/− colons but the numbers of lamina propria CD4+FoxP3+ cells increased in inflammation, with their frequency within the total CD4+ population increasing, based on both flow cytometry and immunohistochemistry data.