HYKK and lung cancer: Polymorphic markers of this particular region were located in the region of the nicotinic acetylcholine receptor gene CHRNA5, CHRNA3 and the aminoglycoside phosphotransferase domain containing 1 gene AGPHD1. There is also evidence that other loci are associated with lung cancer risk: 5p15, which contains the TERT gene and the CLPTM1L gene [15]–[19]; 6p22.1, encompassing the MHC region [3], [15]; 6p21.33 which includes a region where the MSH5 gene (rs3131379) resides [3], [15], [19]; and 6q23-25 locus harboring the RGS17 gene [20]–[22].