In particular, when challenged with a moderately high-fat diet of 32% fat for 26 weeks, Kv1.3-/- mice fail to gain weight compared to their wild-type counterparts, and removal of the olfactory bulb via bilateral olfactory bulbectomy reverses their resistance to this diet-induced obesity (DIO) [8], [13]. The gene discussed is KCNA3; the disease is obesity due to melanocortin 4 receptor deficiency.