Given our previous biophysical characterization of the Kv1.3 channel as a substrate for insulin phosphorylation and modulation [2], our goal was to determine the ability of the olfactory bulb to respond to changes in insulin blood chemistry driven by the physiological fluxes that would typically follow a meal (acute) or during metabolic disease or obese state (chronic). The gene discussed is INS; the disease is Other metabolic disease.