However, in breast cancer patients, the cellular functions of HSP27 that is phosphorylated at various sites (Ser78, Ser82 and Ser15) have been analysed, and it was shown that the phosphorylation of HSP27 at Ser78 but not at Ser15 or Ser82 was significantly correlated with positive HER2 and lymph node status [23]. Here, ERBB2 is linked to breast cancer.