The found fact that HER2 over-expression or amplification predicts poor survival has been seen in many cancer types such as breast cancer [14],[15],[16],[17] or oesophageal adenocarcinomas [18], [19], whereas to our knowledge no studies showed an influence of p-HSP27(Ser15) in human tumour tissue. This evidence concerns the gene ERBB2 and esophageal adenocarcinoma.