Based on IBS and IBD analyses, distantly related samples included MEX pairs NA17673/NA17680 and NA17454/NA17459 (Figure 4A; arrows 1 and 2); CAU pairs NA17203/NA17257 and NA17299/NA17289 (arrows 3 and 4); and CHI pairs NA17785/NA17794 (arrow 5). The gene discussed is ZSWIM2; the disease is irritable bowel syndrome.