We found a highly significant association (P = 1.0×10−124) of the risk allele at the LIPA locus with LIPA mRNA levels in these cells explaining ∼50% of the variance in the expression of the gene (Figure 6).There were no other highly significant associations between CAD risk alleles and gene expression at the novel loci (Table S7a and S7b). The gene discussed is LIPA; the disease is coronary artery disorder.