APOBEC3A and HIV-1 infection: The results presented here indicate that the specific silencing of A3A in differentiated THP-1 cells (that mimic macrophages upon differentiation), primary macrophages and DCs increases their susceptibility to de novo HIV-1 infection, while on the contrary silencing in primary PBLs or ectopic expression of A3A in established cell lines exerts no effect on these phases.