The various studies reported several specific drug offers: sildenafil [59,60,80,84,86,87], benzodiazepines [84,86,87], painkillers [80,84,88], antibiotics [87,88], insulin [87,88], female hormones [87,88], antidepressants [80,84,86], alopecia medications [14,27,80], and obesity medications [59,80]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.