Park et al. [Park et al.,2006] showed the accumulation of p53 protein in as little as 3 hr following BaP treatment in human hepatoma HepG2 cells, while Pei et al. [1999] reported the accumulation of p53 protein after 8 and 24 hr of BaP treatment in A549 and NIH 3T3, respectively. This evidence concerns the gene TP53 and hepatocellular carcinoma.