To establish if miR-34a plays a role in the expression of p53 targets, we examined the mRNA and protein levels of 5 miR-34a targets that were experimentally confirmed in other studies: B-cell CLL/lymphoma 2 (Bcl2), cyclin-dependent kinase 6 (Cdk6), Ccnd1, CcnE2 and E2F3 [Chang et al.,2007; He et al.,2007; Hermeking,2007; Tazawa et al.,2007; Sun et al.,2008]. The gene discussed is CCNE2; the disease is B-cell chronic lymphocytic leukemia.