CASP8 and ovarian carcinoma: Substantial reduce in cell viability was detected in both ovarian cancer cell lines by AUY922 (Figure 6C), and apoptosis was evidenced by caspase 8, and PARP cleavage, a significant increase in caspase 3/7 activity (Figure 6B and 6D), and a dramatic increase in apoptotic cells compared with matched vehicle-treated cells (Figure 6E and Additional File 1, Table S1).