A recent research focusing on another member of JMJD2 family proteins JMJD2B, which is considered to have the similar function as JMJD2A in breast cancer demonstrated that JMJD2B constitutes a key component of the estrogen signaling pathway and the establishment of local epigenetic state and chromatin structure required for proper induction of ER responsive genes. The gene discussed is KDM4B; the disease is breast carcinoma.