A recent research focusing on another member of JMJD2 family proteins JMJD2B, which is considered to have the similar function as JMJD2A in breast cancer demonstrated that JMJD2B constitutes a key component of the estrogen signaling pathway and the establishment of local epigenetic state and chromatin structure required for proper induction of ER responsive genes. This evidence concerns the gene KDM4A and breast cancer.