In the current study, the presence of at least one A allele in -675 T → A SNP and at least one T allele in rs17883901 located, respectively, at the promoter region of the CYBA and GCLC genes modulate the risk for decreased GFR in type 1 diabetes patients even after adjusting for other risk factors. The gene discussed is GCLC; the disease is type 1 diabetes mellitus.