No statistically significant differences were found in frequency of the genotypes T/C+C/C of the SNP GPX3 rs8177412 between patients with and without overt DN (29.8% and 24%, respectively) and between patients with GFR < and ≥ 60 mL/min/1.73 m2 (28.4% and 24%, respectively) (data not shown). Here, GPX3 is linked to liver dysplastic nodule.