Moreno et al. have previously associated the T allele of this SNP with essential hypertension and with a higher phagocytic NADPH-dependent O2•- production in Spanish subjects and they hypothesized that the presence of the T allele increases p22phox transcription by interfering with binding of the transcription factor hypoxia-inducible factor 1-α (HIF-1α) [10]. The gene discussed is HIF1A; the disease is essential hypertension.