APC and Lynch syndrome: In addition, the presence of this MUTYH deletion was screened through PCR in other 183 Brazilian individuals: three APC/MUTYH-mutation negative and 18 APC/MUTYH-mutation positive polyposis patients (12 APC mutation carriers, 5 MUTYH biallelic and one MUTYH monoallelic mutation carriers); 51 clinically suspected Lynch syndrome patients (fulfilling Amsterdan II or Bethesda criteria), who were non-carriers of germline mutations in the mismatch repair (MMR) genes MLH1, MSH2, MSH6 and PMS2; and 111 healthy controls.