MUTYH and colorectal cancer: In the MUTYH gene, a recent study has shown that a polymorphic AluY insertion in intron 15 when in a homozygous state, leads to a 2.15 fold increase in the levels of 8-oxoG in leukocyte DNA and is associated with type 2 diabetes mellitus [23]; however, this insertion has not yet been studied in the context of colorectal cancer.