ERBB2 and neoplasm: Immunohistochemistry (IHC) based tumor tissue mapping techniques were used to investigate changes in JIMT-1 tumors harvested from animals treated for 28 days with 100 mg/kg gefitinib, 1.25 mg/kg RAD001 or the gefitinib and RAD001 combination and in MCF7-HER2 tumors harvested from animals treated for 25 days with 100 mg/kg gefitinib, 1.75 mg/kg RAD001 or the combination.