Tumor volumes of CD151-HepG2-derived xenografts were 1.89±0.6 cm3, which were significantly larger than those of HepG2-CD151-shRNA-CD151 and HepG2-CD151-shRNA- integrin β1 (0.51±0.05 cm3 and 0.47±0.04 cm3, respectively, P<0.01; Fig. 3E). The gene discussed is CD151; the disease is neoplasm.