Serial sections confirmed that pulmonary metastasis rates, and metastatic tumor clusters per mouse were 100% (5/5) and 210±63 in the HCCLM3-mock group, but were 40% (2/5) and 124±55 in the HCCLM3-shRNA-CD151 group, 40% (2/5) and 164±46 in the HCCLM3-shRNA-integrin β1 group, 60% (3/5), and 145±43 in the CD151-HepG2 group. The gene discussed is CD151; the disease is neoplasm.