To further investigate the interaction and role of the CD151/integrin β1 complex in metastasis, we inoculated HCC cells in liver parenchyma of nude mice. Tumor volumes of HCCLM3-mock-derived xenografts were 1.95±0.6 cm3, which were significantly larger than those of HCCLM3-shRNA-CD151 (0.71±0.10 cm3) and HCCLM3-shRNA-integrin β1 (0.59±0.06 cm3). Here, CD151 is linked to neoplasm.