Traditionally, overexpression of CD151 facilitates integrins and growth factor receptors signals, activates Rac and Cdc42, and serves as a transmembrane linker between extracellular integrin domains and intracellular cytoskeleton/signaling molecules, leading to the regulation of actin cytoskeleton, cell spreading, tumor cell motility, and metastasis [26]. The gene discussed is CDC42; the disease is neoplasm.