We also assessed proliferation using the M-phase marker phosphorylated-histone H3 (PH3) and found that 1.7 percent of CSCs and their descendants (YFP cells) were actively in M-phase as compared with less than 0.01 percent of non-stem tumor cells and their descendants (CFP cells, Fig. 4C, D). The gene discussed is PHC3; the disease is neoplasm.