CHDH and type 2 diabetes mellitus: Among NW subjects, we observed nominal association of MTHFR-rs1801133, MTHFR-rs9651118, CHDH-rs4563403, CBS-rs706208, and MTHFD1L-rs1555179 with type 2 diabetes (P value range= 0.002–0.04) (Table 2).