Given that cardiac dysfunction is a major complication in insulin resistance and that Akt-signaling anomalies have been implicated in cardiac dysfunction [17, 26, 27], this study was undertaken to examine the effect of Akt2 knockout on cardiomyocyte dysfunction, if any, and the impact of propionate treatment on Akt2 knockout-induced cardiomyocyte responses. Here, AKT1 is linked to Insulin resistance.