The addition of chemerin augmented the phosphorylation of p38MAPK at 5 to 15 minutes compared with unstimulated RA FLSs, but the level decreased at 30 minutes (Figures 7B and 7H), whereas phosphorylation of JNK1/2 was not promoted by chemerin stimulation (Figures 7C, D, I and 7J). This evidence concerns the gene MAPK8 and rheumatoid arthritis.