MAPT and myeloid sarcoma: An early feature of these changes in MS is phosphorylation of Nf and tau proteins, shown in cell-culture (Jackson et al., 2004), animal models (Anderson et al., 2008; Schneider et al., 2004) and post-mortem tissue (Dutta et al., 2006; Petzold et al., 2008; Trapp et al., 1998).