BRCA2 and breast neoplasm: To follow up on these results, we have studied copy-number changes in a larger number of BRCA2 tumors by high-resolution array-comparative hybridization (aCGH) microarrays containing 385 thousand probes (about one for each 7 kbp) in breast tumors derived from BRCA2 germline mutation carriers (n = 33) combined with analysis of phenotypic markers by immunohistochemistry (IHC) on tissue microarrays (TMAs).