ALDH1+ status was found in all clusters, but less common in Cluster D. Multivariate survival analysis adjusted for age, node status and tumor size showed significantly worse outcome for Cluster C and D compared to Cluster B (HR = 2.1, 95% CI = 1.1 to 4.3, P = 0.03 respective HR = 2.1, 95% CI = 1.1 to 4.4, P = 0.04), respectively, but no significant difference between Cluster A and Cluster B. This evidence concerns the gene ALDH1A1 and neoplasm.