NFKB1 and cancer: Knowing the involvement of NF-κB pathway in the regulation of multidrug resistance (MDR1) and anti-apoptotic genes (Bcl-2 and Bcl-xl) [9], we now aimed to investigate whether 15d-PGJ2 is capable of inducing apoptosis in doxorubicin-resistant cancer cells compared to the wild-type.