To investigate in vivo erythropoiesis by darbepoetin alfa and EPO-hyFc(H) in cisplatin-induced anemic rats, rats were treated with 6 mg/kg cisplatin via intraperitoneal route, leading to decreased Hb concentration up to around 12 g/dL showing mild anemia. This evidence concerns the gene GSTM1 and anemia (phenotype).