We demonstrate that while this WDPMP tumor does not exhibit any of the chromosomal aberrations and focal deletions commonly associated with asbestos-related mesothelioma [5], it does exhibit the first reported somatic single nucleotide mutation of E2F1 (E2F transcription factor 1) in cancer, with the mutation affecting one of two evolutionarily conserved arginine residues responsible for motif recognition and DNA binding. The gene discussed is E2F1; the disease is mesothelioma.