BAP1 and mesothelioma: It is interesting to note that BAP1 (BRCA1 associated protein-1), a nuclear deubiquitinase affecting E2F and Polycomb target genes, was recently shown to be inactivated by somatic mutations in 23% of MPMs [36], suggesting that the genes within the E2F pathways might play an important role in mesothelioma in general.