RASSF1 and malignant mesothelioma: Figure 2 shows the Hilbert plots of the sequenced tumor, tumor-derived cell line and normal blood sample exomes, revealing some systemic capturing biases but no deletion/amplification events, with particular attention paid to known somatic deletions of 3p21, 9p13~21 and 22q associated with loss of RASSF1A (RAS association family 1A), CDKN2A (cyclin-dependent kinase inhibitor 2A) and NF2 (neurofibromin 2) genes, respectively, in malignant mesothelioma [12].