HLA-DRB1 and Infertility: On the other hand, comparison of cryptorchid boys with familial cryptorchidism and/or infertility to control boys revealed highly significant (pcorrected = 0.0006, O.R. = 4.304) difference in HLA-DRB*11 frequency, whereas boys with sporadic cryptorchidism did not differ from control (Table 3).