In our predicted mouse NSCs related network NSC-GN2, three genes which regulate Tmem59 directly are identified as sncg, cd59a and myrip. Sncg (γ-synuclein) has been identified to be correlated to dementia hippocampus of AD and pathology of Parkinson's disease (PD) [55]. The gene discussed is TMEM59; the disease is Alzheimer disease.