In NSC-GN2, our study showed that 17 out of 37 predicted genes (including tmem59) are related to AD in NSC-GN2: Ace [36], aqp1 [37], arrdc3 [38], cd14 [39], cd59a [40], cds1 [41], cldn1 [42], cox8b [43], defb11 [44], folr1 [45], gdi2 [46], mmp3 [47], mgp [48], myrip [49], Ripk4 [50], rnd3 [51,52], and sncg [53]. This evidence concerns the gene RND3 and Alzheimer disease.