Furthermore, a pooled analysis of two studies which provided genotype frequencies in patients with no, one, two, or three vessel disease showed, a greater prevalence of the PT G20210A genotype among patients with no or one vessel disease than in those with multi-vessel disease (4.4% vs 2.2%) suggesting that the 20210A prothrombin gene variant may be a significant genetic factor for hypercoagulability in patients with ischemic heart disease but limited atherosclerotic involvement [11,19,20]. This evidence concerns the gene F2 and thrombophilia.