While absent or weakly expressed in benign prostatic glands (Figure 1A), RBM3 was clearly up-regulated in prostatic intraepithelial neoplasia (PIN) (Figure 1B) and in invasive carcinoma RBM3 was expressed in various fractions and intensities (Figure 1C-E) with 33 (37.5%) cases lacking RBM3 expression (Figure 2). This evidence concerns the gene RBM3 and male reproductive organ cancer.