In saline PAR2-/- (n = 11) and ANG II PAR2-/- (n = 12) the cirazoline CRC were shifted to the left (more potent) of saline C57 (n = 27) and ANG II C57 (n = 33), respectively [***P < 0.0005, two way ANOVA effect of strain on -logEC50: saline PAR2-/-, 7.7 ± 0.1; ANG II PAR2-/-, 7.7 ± 0.1; saline C57, 7.4 ± 0.1; ANG II C57, 7.4 ± 0.1]. This evidence concerns the gene F2RL1 and colorectal carcinoma.