The LNA-nucleolin DNA aptamer (molecule present on cancer cell surfaces and translocated to nucleus) (Soundararajan et al., 2008) and LNA-EpCAM RNA aptamer (Shigdar et al., 2011), known to be over-expressed on the apical side of the cancer cell surfaces were prepared (Hertoghs et al., 2003) and loaded individually or in combination on these Fe-bLf-SPOINS nanocarriers. The gene discussed is EPCAM; the disease is cancer.