In another study 2'-F modified anti-PSMA aptamer (A-10) was covalently linked to sense strand of 21-mer siRNA hybridized to 21-mer antisense strand, the resulting chimeric was shown to selectively internalize into cells expressing PSMA and inhibit expression of targeted tumor survival genes (Plk1 and Bcl2) aptamer. Here, FOLH1 is linked to neoplasm.