The PTEN loss in cancer states invokes unopposed AKT activity and phosphorylation of various substrates that enhance cell survival, including pro-caspase 9 (Cardone et al, 1998), BAD (Datta et al, 1997) and the forkhead factor, FKHR (Biggs et al, 1999). The gene discussed is AKT1; the disease is cancer.