The three-fold induction of FGFR1 expression observed in the development of CRPC is the highest among the genes activated in the second-ranked network, and along with the reported contribution of FGFR1 in PC biology, we would propose that FGFR1 is the gene of interest rather than a proxy or downstream effect of an independent tumour-promoting event. This evidence concerns the gene FGFR1 and pachyonychia congenita.