Interestingly, deactivation of FGFR1 in early cancers leads to complete tumour regression, suggesting a role in both initiation and progression (Acevedo et al, 2007), As we have discovered significant association between FGFR1 upregulation and CRPC, future investigation using castration experiments on this transgenic FGFR1 PC mouse model may provide insight into the impact of abnormal FGFR1 function in the development of CRPC. This evidence concerns the gene FGFR1 and cancer.