LGALS1 and brain ischemia: Considering that i) reactive astrocytes could play a crucial role in preventing the enlargement of the infarcted region after brain ischemia [34,37], ii) reactive astrocytes express Gal1 (Figure 1B) [16], iii) Gal1 regulates the proliferation of reactive astrocytes [16], iv) soluble Gal1 binds to β1 integrin [18,38], which regulates the migration of astrocytes [39,40], hGal-1 could influence the proliferation and/or migration of reactive astrocytes after brain ischemia, resulting in a reduction in the size of the ischemic region.