ADIPOQ and pulmonary emphysema: Also an increased production of pro-inflammatory cytokines in alveolar macrophages resulting in emphysema-like pathogenesis in adiponectin-deficient mice was described and pre-treatment of the alveolar macrophage with adiponectin lead to suppressed secretion of pro-inflammatory cytokines indicating adiponectin as a potent anti-inflammatory molecule [23] and adipokine receptors being expressed in the murine lung already during embryogenesis [24].