Interestingly, although particle challenge in general increased PAI-1, CXCL1, and MIP2/CXCL2 concentrations in BAL, HF animals revealed at least at trend lower BAL macrophage inflammatory protein 2 (MIP2) values in comparison to LF and CA mice, respectively, and therefore may indicate a lower degree of macrophage pro-inflammatory activation which in turn partially may be responsible for an absence in the extent of neutrophil influx among groups. This evidence concerns the gene SERPINE1 and hydrops fetalis.