At the myotube stage, the increase in the number of genes that were dysregulated in FSHD cells may be partly due to the FSHD-associated decreases in expression of the transcription regulatory MYF6 and MEF2A genes and abnormal increases in expression of MEIS2 after induction of differentiation to myotubes. Here, MEIS2 is linked to facioscapulohumeral muscular dystrophy.