A number of 4q35 genes have been considered as candidates for the initially dysregulated gene during FSHD pathogenesis, namely, FRG1, DUX4, DUX4C, ANT1 (SLC25A4), FRG2, TUBB4Q, and FAT1 [6,17-24]. This evidence concerns the gene FAT1 and facioscapulohumeral muscular dystrophy.