An example of such infrequent overlap is the upregulation of the vascular smooth muscle-associated CTGF, ENG, and TAGLN genes in FSHD vs. control muscle [12] and, in this study, in FSHD vs. control myotubes (2- to 3-fold upregulation, p < 0.001 for all comparisons). This evidence concerns the gene CCN2 and facioscapulohumeral muscular dystrophy.