TP63 and melanoma: In accordance with this apparent decrease in p63 activity in metastatic melanoma, we found that there was a significant decrease in the transcription of the TP63 gene itself in these samples (p = 2.2 × 10-10 and 4.1 × 10-3 for GSE8401 and GSE7553, respectively, by Student's t test; metastatic vs. primary melanoma only).