TP63 and acne: For example, MARQ identified E2 signaling as downregulated in MCF7 cells treated with dioxin, which is a well-known antiestrogenic agent [45], and identified p63 signaling as being upregulated in acne lesions compared with normal skin and in the bronchial epithelium of smokers compared with that of nonsmokers (both of which may reflect squamous repair mechanisms in injured or inflamed tissue).