Moreover, the authors gained further results on an additional exon 12 single nucleotide polymorphism (SNP) of the ATP7B gene associated with Alzheimer's disease and in linkage disequilibrium with the exon 10 SNP one, suggesting that exon 12 or something very close to it can be a susceptibility locus for Alzheimer's disease (R. Squitti personal communication). Here, ATP7B is linked to early-onset autosomal dominant Alzheimer disease.